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Spanish scientists design a drug against diseases such as asthma or psoriasis
29 December 2016

      I have just found a very interesting news, for many people, all over the world:  “Some Spanish scientists design a drug capable of curbing a wide range of autoimmune diseases such as asthma or psoriasis”.

      Spanish scientists have designed a drug capable of curbing a variety of autoimmune diseases such as asthma, psoriasis, Crohn's disease or multiple sclerosis, but without blocking the body's natural response, against infections caused by pathogens.

Psoriasis on one arm

        The compound, an inhibitor of T lymphocyte activation, is the result of the work of 32 Spanish researchers from the CSIC, the Institute of Biomedical Studies August Pi i Sunyer (IDIBAPS), the National Center for Cardiovascular Research (CNIC) and the Princess Hospital of Madrid, mainly.

      The study, led by Balbino Alarcón of the Center for Molecular Biology Severo Ochoa, has been published in Science Translational Medicine.

      "The new drug, which has been tested in healthy volunteers and has passed the toxicity tests, on the contrary of many of the current treatments of autoimmune diseases, that are based on the use of antibodies and are administered intravenously, is taken orally and has, in addition, a long-lasting effect", Alarcón has explained, in declarations to Efe.

      In mouse models "we have seen that it has effects even when the compound ceases to be administered, which means that a treatment, for a short time, could be enough to cause the symptoms of the disease to go away, without having to medicate the patient for life", Alarcón has noted.

      The compound is not immunosuppressive but allows, at least in mice, the body to activate the natural response, against pathogens (viruses, bacteria, parasites or fungi), while being effective in autoimmune diseases.

       In this way, it ends with the usual problem of the current drugs, that, to treat autoimmune diseases, cancel the body's natural ability to fight infections, "which makes these patients very sensitive to infections".

       Alarcón has detailed that the compound inhibits the activation of T lymphocytes, which are responsible for detecting the body's antigens, which can be either own (in tissues and organs) or foreign (those that pose a threat and a potential infection).

      For their work, T lymphocytes have an essential receptor: the receptor for TCR antigens, which transmits information to the interior of the lymphocyte cell, to indicate that it has detected or recognised an antigen (external or not), information that is transmited through different proteins, that are inside the cell. One of them is the NCK. "When TCR recruits NCK or joins it inside the cell, it transmits information indicating that it has recognised an antigen".

      The drug inhibits or blocks the interaction among TCR and NCK and thus "makes T cells stop responding to their own antigens, in an autoimmune disease, and to fight the external antigens of an infectious process. It is its differential effect”.

      The company Artax Biopharma (USA, UK, Spain) has carried out Phase I trials of the drug, with healthy volunteers, and it is now studying the possibility of taking it to clinical stage, in different diseases.

      Well, I hope this discovery works well, in different hospitals, and can cure many patients.

      Until my next post, kind regards,

Luis.

Sponsored by Costaluz Lawyers.

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World Heritage Cities of Spain
22 December 2016

The poster of the World Heritage Cities - SPAIN - UNESCO

 

Map of the World Heritage Cities in Spain

Alcalá de Henares:

General view of Alcala de Henares

The Cervantes Square in Alcala de Henares

Cervantes and his Square in Alcala de Henares

Another view of Cervantes Square in Alcala de Henares

The famous University of Alcala de Henares

      Surely, this is one of the oldest Universities in the world.

Mayor street of Alcala de Henares

Tourist Parador of Alcala de Henares

Ávila:

A general view of Avila

Avila and its Cathedral

Avila and its famous wall

      Avila is a member of an International Association of Cities with walls.

San Pedro church at the Santa Teresa Square

Baeza:

The Cathedral of Baeza

Street of Baeza

Jabalquinto Palace in Baeza

Cáceres:

General view of Cáceres

Mayor Square of Caceres

Hotel Alfonso IX in Cáceres

Ancha street in Caceres

Córdoba:

Córdoba and its Mosque-Cathedral

The Mosque-Cathedral from the Guadalquivir river

The triumph of San Rafael and the Mosque-Cathedral from the Roman bridge

Inside of the Mosque-Cathedral

Another nice view of the Mosque-Cathedral

Ruins of Medina-Azahara

Backstreet of the Flowers with the Mosque-Cathedral at the end

A typical patio of Córdoba

A horsewoman with the typical hat of Cordoba in the Feria, in May, each year

Cuenca:

A view of Cuenca

Another view of some houses in Cuenca

Some suspended houses in Cuenca

Mayor Square of Cuenca

Ibiza:

A view of Ibiza village

A nice cove of Ibiza

Ibiza at night

Mérida:

General view of Mérida

Spain Square of Mérida

Santa Eulalia Street in Mérida

The famous Roman Theatre of Mérida

Salamanca:

A general view of Salamanca

Salamanca and its Cathedral on the left side of the picture

The Cathedral with the Tormes (an affluent of the Duero river) in Salamanca

Mayor Square of Salamanca

A street of Salamanca with the tower of the Cathedral to the end

The famous Salamanca University

The patio of the University

San Cristóbal de La Laguna:

General view of San Cristobal de La Laguna

Pedestrian street Bishop Rey Redondo

Tower of the church La Concepcion at the end of the Bishop Rey Redondo

The Cathedral of San Cristobal de La Laguna

A carpet of flowers in the feast of Corpus Christi, in May or June

Santiago de Compostela:

General view of Santiago de Compostela

Close to the Cathedral

A street of Santiago

Segovia:

Segovia and its Cathedral

The famous Aqueduct of Segovia, on the right side of the picture

"Meson Cándido", at the end of the Azoguejo Square

      Close to the Aqueduct, where some light shine, you can eat the famous piglet in the "Meson Candido", where the own Cándido is able to cut the whole piglet with only a plate.

Meson Cándido

Cándido carving some piglets 

The Fortress of Segovia

Juan Bravo street with the >Cathedral at the end in Segovia

Aqueduct of Segovia and a part of the city

 

Tarragona:


A general view of Tarragona

The Cathedral of Tarragona


Prim Square in Tarragona

Ruins of the Roman Circus in Tarragona

Another nice view of the ruins of the Roman Circus

A restaurant inside some Roman ruins


A group of famous Castellers

 

Toledo:

Panoramic view of Toledo

       Toledo has housed three cultures: the Muslim, the Christian and the Jewish.    

Alcázar and Cathedral of Toledo

The Alcázar of Toledo

Panoramic view of the Cathedral of Toledo

The Cathedral of Toledo close up

Inside the Cathedral of Toledo

Street and arch in Toledo

Another nice street of Toledo

Upstairs of La Granja in Toledo

The famous feast of the Corpus Christi in Toledo

 

Úbeda:

Panoramic view of Ubeda

Another view of Ubeda

The Vazquez de Molina Square and El Salvador Chapel in Ubeda

Inside Ubeda

      Well, I hope that you have liked this article and hope that you have not considered it too much long.

      Until my next post, kind regards,

Luis.

Sponsored by Costaluz Lawyers.

Please click below:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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