Mediterranean Diet: Should You Drink Wine or Eat Grapes?

Published on 04/11/2007 in Spanish Lifestyle

Red wine and grapesThe French paradox

In studies conducted in 1992, it was observed that in southern France, mortality rates from heart disease were lower than expected despite the consumption of diets high in saturated fat. Researchers attributed the impressive low incidence of heart disease, 50 percent lower than in the Unites States, to the consumption of red wine. Since then, the possibility that drinking red wine might protect our heart arteries, has made the topic “wine and health” extremely popular. In fact, research has shown that taken in moderation -two 8 ounces glasses for men and 1 glass for women per day, red wine may increase HDL cholesterol, the “good” guy, decrease LDL cholesterol, the “bad” one, prevent oxidation of LDL, and scavenge free radicals.
What is the secret in red wine?

Since the discovery of the “French Paradox” puzzle in 1992, researchers have been trying to pinpoint why red wine has a cardiovascular protective effect. While studies have been focusing in the antioxidant properties of red wine, evidence suggests other mechanisms by which it might be beneficial for our health. Research points toward a family of substances called polyphenols which are found in plants and are abundant in grapes. Polyphenols are part of a larger family known as phytochemicals.

Phytochemicals: Medicine of the future

The word “phyto” means “plant” in Greek. Phytochemicals are nonnutritive chemicals found in plants that protect us against diseases. Many fruits and vegetables contain a wide variety of phytochemicals; in fact, researchers have identified by now more then 900 different phytochemicals in foods and they are not done yet, since every day they discover new ones. It is estimated that there may be more than 100 different phytochemicals in just one serving of fruit or vegetables.
Studies have long shown that phytochemicals are present in plants to protect them, but only recently we have learned that they are also crucial in protecting humans against diseases. We know that people who consume plant foods regularly have a lower incidence of heart disease than people who do not include them in their diet.

How can phenol-phytochemicals protect our arteries?

Polyphenols can protect our arteries through the following mechanisms:

  • Lowering LDL cholesterol in the blood. A study conducted to evaluate the effect of moderate Sicilian red wine consumption on cardiovascular risk factors found out that at the end of the red wine intake period, 4 weeks, LDL cholesterol and oxidized LDL had significantly decreased, while HDL Cholesterol and the total antioxidant capacity of the blood had increased¹.
  • Recycling vitamin E as an antioxidant. This is very important because vitamin E represents the first line of defense against LDL oxidation. Once vitamin E is exhausted, LDL cholesterol is no longer protected until the vitamin can be reactivated by agents such as polyphenols.
  • Increasing the production of nitric oxide, a substance that causes the arteries and veins to relax.
  • Preventing platelets from sticking to the inside walls of the arteries. Platelets are tiny particles found in the blood that play an important part in the clotting process².

Red versus white wine

White wines have shown the ability to prevent the oxidation of LDL but generally are not as effective as red wines. Polyphenol content of red wine can be about 20 times higher than in white wine and it has been observed in several studies that the antioxidant potential of red wine is six to ten times higher than white wine. About eight times more of white wine is required to produce an effect equal to red wine on preventing the oxidation of LDL cholesterol. Three factors account for these results:

  • Grape skins are not included in the production of white wine.
    Red wine is made with whole grapes, including skins
  • The skins of red grapes contain higher amounts of polyphenols than the skins of white grapes.

Wine or grapes for healthy arteries?

 If the polyphenols in grapes are mostly in the skins, can we just have red grapes or red grape juice, which is also made with the grape skins, and obtain the same beneficial effects as drinking red wine? Yes, we can, researchers tell us.

This study, among others, showed that red grape juice and dealcoholized red wine can significantly reduce arterial disease by lowering the level of oxidized cholesterol, preventing platelets to stick together, and enhancing the production of nitric oxide³.  In another study, grape juice proved to be more effective than red wine or dealcoholized red wine in inhibiting arterial disease at the same polyphenol dose. The researchers concluded that grape juice or non-alcoholic red wine are an excellent alternative to red wine when in comes to disease of the arteries.


Although research has shown that in the absence of contraindications, moderate red wine drinking, two 8 ounces glasses for men and 1 glass for women per day, may be beneficial to patients who have a cardiovascular condition, those health effects disappear very fast and can have serious health implications when we abuse drinking. And since studies indicate that most of the beneficial effects of drinking red wine are attributable to the polyphenols present in grapes, we may conclude that a diet that includes grapes as well as other fruits and vegetables containing polyphenols may be even more beneficial.


1. G Avellone, G, Di Garbo, V,  Campisi D,  De Simone R, Ranel G,  Scaglione R and  LicataG. Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis European Journal of Clinical Nutrition (2006) 60, 41–47. doi:10.1038/sj.ejcn.1602265.
2. Ruf JC. Alcohol, wine and platelet function. Biol Res. 2004;37(2):209-15.
3. Vinson, JA, Teufel, K, Wu, N. Red wine, dealcoholized red wine, and especially grape juice, inhibit atherosclerosis in a hamster model. Atherosclerosis. 2001 May; 156(1):67-72.
4. Folts, JD. Potential health benefits from the flavonoids in grape products on vascular disease. Adv Exp Med Biol. 2002; 505:95-111.

Written by: Emilia Klapp

About the author:

Emilia Klapp has a Bachelor in Nutrition Science and is certified as a Registered Dietitian by the American Dietetic Association. With her book “Your Heart Needs the Mediterranean Diet”, she has helped many people to prevent high blood pressure and high cholesterol. For more information about the author and the book you can login at

Right arrow icon Send to friends   Right arrow icon Printer friendly version    Right arrow icon Submit your own article


Barabara said:
05 April 2011 @ 00:43

Thanks for the interesting article.

Only registered users can comment on this article. Please Sign In or Register now.

Comment Using Facebook:

Related articles in this category

5 Last Minute Tapas to Make at Home

A Spanish Dish To Include In Your Christmas Menu

All In All, Spain Delivers A Better Quality of Life

An Introduction to the world of olive oil

Budgeting in Spain

Buying a Berth For Your Boat in Spain

Christmas in Spain

Clothes Shopping in Spain

Costa de la Luz - Shhh, keep it a secret

Eating Habits in Spain - What you need to know

Friends in Spain, They Come And Go

Golfing in Costa de la Luz

Gourmet Delights In Southern Spain

Homemade Spanish Gazpacho Soup

Hotel Molino del Puente

How To Make A Tortilla Española "de San Sebastián"

Live in Spain But No More Holidays

Living in Puerto de la Duquesa

Mediterranean Diet – Eat Fruits and Vegetables to Maintain a Healthy Blood Pressure

Mediterranean Diet: 5 Ways to Living a Longer, Stronger Life Without Heart Disease

Mediterranean Diet: Can Garlic Protect Us From More Than Vampires

Mediterranean Diet: How to Lower Cholesterol Effortlessly by Including More Tomatoes in Your Diet

Mediterranean Diet: Mending Your Arteries after the Holidays

Mediterranean Diet: Should You Drink Wine or Eat Grapes?

Mediterranean Diet: Why You Should Make Extra Virgin Olive Oil Part of Your Diet

New Year - Are You Ready For A New Lifestyle?

Out and About in Duquesa

Quotes To Sum Up Life In Spain

Relax And Unwind On The Costa Calida

Seven Tips To Help You Learn Spanish

Spain is Character Building

Spain Vs Italy - Let The Gastronomic Battle Commence

Spanish Coasts: North Vs South

Spanish Food

Spanish Telly At Christmas

Spanish Wills

Sukhothai - A Thai adventure in Marbella

Surviving the Spanish Weather in Summer

The Absence Of Women In Spanish Bars

The Claims Sheet - Consumer Rights

The end of poor service and rogue traders?

The Mediterranean Diet - What's it About?

The Mediterranean Diet Is Also About Portions

Top 10 Spain Christmas Gifts

Top Destinations in Costa de la Luz

Tourists are Doing it for Themselves

Urbi et Orbi …

Visiting the Hairdressers in Spain

Weather Patterns in Spain

What Happens When English Gets Mixed With Spanish In Spain?

Why I Chose Costa de la Luz to Live

Why The Spanish Football League Is A Truly Unique Sporting Stage

Will Golf Ever Go Out?

Working From Home In Spain

Click here for a list of all the articles from our magazine 

Spain insurance services

This site uses cookies. By continuing to browse you are agreeing to our use of cookies. More information here. x