Researchers at the University of the Basque Country (UPV / EHU) and the CIC biomaGUNE ( a non-profit research organization created to promote scientific research and technological innovation at the highest levels in the Basque Country) have discovered the importance of a molecule in episodes of cerebral ischemia or stroke that could lead to development of new therapies to alleviate brain damage and neurological disorders, caused by this stroke.
The cerebral ischemia is the third leading cause of death and the leading cause of disability in the industrialized countries. It occurs as a result of the temporary or permanent reduction in cerebral blood flow and it causes an irreversible neuronal damage, that causes neurological disorders, as reported by the UPV, in a statement.
Images of consequences on brain ischemic strokes
An important part of this decline is due to altered levels of glutamate, the most abundant excitatory neurotransmitter of the brain, that in turn acts as a potent neurotoxin, when its concentration rises, as occurs during ischemia.
The new discovery shows that the molecule cTX, the cystine-glutamic exchanger, is accumulated to lethal levels for neurons, during ischemia.
So it has been proved by the researchers, in experimental models, that reproduce the main features of sudden stroke, in patients.
In turn, the researchers at CIC biomaGUNE, by functional brain imaging techniques such as PET (from English, Positron emission tomography) have observed that xCT levels are elevated, in rats subjected to ischemia, underscoring its importance in stroke process.
In conclusion, it derives this research, developed in experimental animals, opens the door to development of new neuroprotective treatments, by drugs conducted against the xCT exchanger, in order to cerebral ischemia.
The results of this study have been published, in open, by the Journal of Clinical Investigation.
From the part of Biscay, the research has been led by the researchers María Domercq and Carlos Matute, from the centre Achucarro and UPV / EHU, and, from Gipuzkoa part, by Abraham Martin, a researcher at CIC biomaGUNE of Donostia - San Sebastián.
Well, I hope that you have liked this news. Hopefully this research gets make disappear this hard disease.
Till next time, kind regards,
Luis.
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